ZnO-5FU against MCF7

Herein, an approach for new modification of 5-fluorouracil (5-FU) drug, which is widely used for treatment of cancer by inhibiting essential biological processes. Recently, understanding of the treating mechanism of 5-FU led to improving new ways to raise its activity. In this book, we modify the drug function by combining it with ZnO nanoparticles which are exceedingly used by researcher in the field of anticancer drug development. Anticancer activity of ZnO reveals to production of Reactive Oxygen and ions. Moreover, zinc oxide was prepared by Sol-gel method. Different characterizations held on to confirm the structure and morphology of the obtained samples. In addition, DPPH, SOD and GPx radical scavenging activity was applied to investigate the antioxidant activity. Cytotoxicity of MCF-7 was determined by MTT assay, flow cytometry and RT-PCR which confirms that (ZnO-5FU) will be a promising efficient drug for treatment of breast cancer.