Tyrosine Phosphorylation/Dephosphorylation and Downstream Signalling

Nearly every cellular activity, such as cell growth,

proliferation, protein synthesis, and nuclear division, is

regulated by protein phosphorylation/dephosphorylation on

tyrosine residues as initiation events.Synchronization

occurs through interaction of protein tyrosine kinases and

phosphatases.

This book unveils signal pathways that connect

extracellular signals with changes of phosphorylation state

of target proteins allowing coordinated and integrated

modulation of mitogenic signalling. Specifically, cascades

involving protein serine/threonine kinases and connections

to phosphoinositides derived second messengers are

discussed.