Transdermal Drug Delivery System

In the recent years, controlled release of drug from the suitable delivery system has attracted academic and industrial researchers and has been coveted approach to improve therapeutic efficacy. Hence, formulation and in vitro evaluation of losartan potassium (LP) loaded transdermal delivery system (TDS) was investigated for controlled release and improved therapeutic efficacy. TDS in the form of patches were prepared by varying the composition of Eudragit RL 100 and Eudragit RS 100. Patches were evaluated for thickness, content uniformity, mechanical properties, moisture uptake and in vitro drug release. Technological parameters for all the formulations were found to be within the limit. In-vitro studies showed relatively low permeation of LP. Inclusion of penetration enhancers (capsaicin & pluronic F-68) resulted increased permeation of LP across human skin. Additionally, study also describes an appropriate animal model for the prediction of human skin permeability. This book provides comprehensive research methodology of TDS & various quality control parameters for the beginners to understand & develop interest in transdermal drug delivery research.