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Hardcover - 9789811088056
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Beschreibung
This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) – teixobactin and the skyllamycins – with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the
Pseudomonas aeruginosa
biofilms that are responsible for significant mortality among cystic fibrosis patients.
Details
| Verlag | Springer Singapore |
| Ersterscheinung | 14. Februar 2019 |
| Maße | 23.5 cm x 15.5 cm |
| Gewicht | 446 Gramm |
| Format | Softcover |
| ISBN-13 | 9789811342455 |
| Seiten | 268 |
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