Pro-inflammatory cytokines have been implicated in a wide range of central nervous system (CNS) disorders, including trauma, ischemia, multiple sclerosis and Alzheimer's disease. Tumour necrosis factor-¿ (TNF-¿) and interleukin-18 (IL-18), both pro-inflammatory cytokines, have previously been shown to attenuate long-term potentiation (LTP), a proposed model for learning and memory. This study investigated the mechanisms underlying the TNF-¿ and IL-18 mediated inhibition of LTP. Initial experiments consolidate evidence on inducing LTP in the dentate gyrus of the hippocampus. Subsequent experiments consolidate evidence that TNF-¿ and IL-18 can impair LTP in the dentate gyrus.
Tags: Biologie, Biochemie, Biophysik
Taschenbuch - 9783844319941 Verlag: LAP Lambert Acad. Publ. Ersterscheinung: Juli 2011 ISBN-13: 9783844319941 Größe: 220 mm x 150 mm x 16 mm Gewicht: 403 Gramm 260 Seiten Versandfertig in 3-5 Tagen.