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Beschreibung
Pro-inflammatory cytokines have been implicated in a wide range of central nervous system (CNS) disorders, including trauma, ischemia, multiple sclerosis and Alzheimer¿s disease. Tumour necrosis factor-¿ (TNF-¿) and interleukin-18 (IL-18), both pro-inflammatory cytokines, have previously been shown to attenuate long-term potentiation (LTP), a proposed model for learning and memory. This study investigated the mechanisms underlying the TNF-¿ and IL-18 mediated inhibition of LTP. Initial experiments consolidate evidence on inducing LTP in the dentate gyrus of the hippocampus. Subsequent experiments consolidate evidence that TNF-¿ and IL-18 can impair LTP in the dentate gyrus.
Details
| Verlag | LAP LAMBERT Academic Publishing |
| Ersterscheinung | 08. März 2011 |
| Maße | 22 cm x 15 cm x 1.7 cm |
| Gewicht | 405 Gramm |
| Format | Softcover |
| ISBN-13 | 9783844319941 |
| Seiten | 260 |
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