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Beschreibung
The efficacy of delavirdine is lower than other FDA approved NNRTIs, therefore, the US department of health and Human Services has recommended its use not as a part of initial therapy but in combination with other drugs. To circumvent this therapeutic difficulty of delavirdine, we amended its structure to develop a novel analogue by replacing its less active indole fragment with a more active anti-HIV prone isatin¿s Mannich bases. The molecular assemblage of delavirdine was concurrently also altered by rearranging its vital fragments to allow it to emerge with altogether a different molecular setting.
Details
| Verlag | LAP LAMBERT Academic Publishing |
| Ersterscheinung | 14. November 2014 |
| Maße | 22 cm x 15 cm x 0.5 cm |
| Gewicht | 107 Gramm |
| Format | Softcover |
| ISBN-13 | 9783659635229 |
| Seiten | 60 |