Synthesis and Biological Activity of Some Mannich Bases

The study of the chemistry of Mannich bases is interesting in many aspects; Mannich bases are important intermediates in organic synthesis. Also these molecules are biologically interesting. Many Mannich bases exert potential antibacterial, antifungal, antiviral, antimalarial and antitumor activities. Hence these bases are important for drug discovery. This work was aimed to synthesis of a panel of ketonic and phenolic Mannich bases, elucidation of structures of the targeted molecules via sensitive analytical tools, and evaluation of the synthesized molecules for their antimicrobial activity. Nine Mannich bases were synthesized via a general synthesis protocol. The structures of the synthesized molecules were deduced on the basis of their spectral data (UV,IR,1HNMR and MS). The targeted Mannich bases were screened for their antibacterial and antifungal activities against six standard human pathogens and significant results were obtained. This work could be beneficial for researchers in the field of organic synthesis. It could also be of interest for those who are involved in drug design.