Synthesis and Antimicrobial Activity of Chalcone and their Derivatives

Medicinal chemistry explains the design and production of compounds can be used for the prevention, treatment or cure of human and animal diseases. Medicinal chemistry includes the study of already existing drugs of their biological properties and their structure activity relationships. The chemistry of heterocyclic compounds is those, which have a cyclic structure with two or more different kinds of atoms in the rings. Heterocycles containing nitrogen are most abundant in nature than those containing oxygen or sulphur. Heterocyclic compounds are very widely distributed in nature and are essential to life in various ways, most of the sugars and their derivatives including vitamins and some member of Vitamin-B group possess heterocyclic ring containing nitrogen as a hetero atom. Quinoline contains a phenyl ring fused to a pyridine ring. It is also known as benzpyridine. Quinoline based chalcones have been reported to possess antimalarial activity.