Synthesis and Antibactarial Evaluation Novel Triazol Derivatives

Heterocycles bearing a triazole ring residue are reported to show anticancer, anti-inflammatory, analgesic, antifungal, antitubercular, antimicrobial, antiviral, antioxidant, CNS depressant, and plant growth regulatory activity etc. Keeping in view the importance of Triazole from the literature survey I found various triazole derivatives & from that I planned to work the substituted triazole derivatives from m-nitro benzoic acid, which gives various anticipated biological activities. Among the all synthesized compound, compound 6-(2-chloro-phenyl)-3-(4-nitro-phenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole (PLP 105b) with MIC value of (16µg/ml) against gram-positive (B.subtilis) and (16µg/ml) against gram-negative (E.coli,p.aeroginosa)and the compound3,6-bis-(4-nitro-phenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole (PLP 105d) with MIC value of (16µg/ml) against gram-negative (p.aeroginosa) give better antimicrobial activity than other synthesized compound.