Superporous Hydrogel Tablets of Clarithromycin

Superporous hydrogels (SPHs) were developed to retain the drug in the gastric medium. These systems swell very rapidly in the stomach and preserve their integrity for a longer time even in the acidic environment of the stomach while releasing the pharmaceutically active ingredient. The present work focuses on the concept of the development of superporous hydrogel tablets of Clarithromycin, and their comparativeness to the marketed delayed-release dosage forms. The aim of this study was to prepare a gastroretentive dosage form based on SPH using Clarithromycin, as an ideal drug for swelling & prolonged drug release characteristics in acidic pH. The formulation is based on the preparation of third-generation SPHs with three altered polymers, such as sodium alginate, pectin, chitosan, and acrylic acid were used with different concentrations by a crosslinking technique using formaldehyde as a cross-linking agent to get the preferred sustained release profile over a period of 8-12 hrs.