Chemistry and Biology of Pteridines / St. Andrews, Scotland, September 21–24, 1982

Frontmatter -- Preface -- ACKNOWLEDGEMENTS -- PARTICIPANTS -- Contents -- The Gowland Hopkins Lecture: Transport of Folate and Pterin Compounds / Huennekens, F.M. / Suresh, M.R. / Grimshaw, C.E. / Jacobsen, D.W. / Quadros, E.T. / Vitols, ¿.S. / Henderson, G.B. -- Chemical Aspects (1) -- Scottish International Education Trust Lecture: Synthetic Methods in Pteridine Chemistry: Some Applications to Pteridine Natural Products / Taylor, Edward C. -- Synthesis, Chemical and Enzymatic Properties, and Therapeutic Potential of 6,6-Disubstituted Tetrahydroand Quinoid-Dihydro-Pterins / Bailey, Steven W. / Ayling, June E. -- The Structure of Quinonoid Dihydropterins [2-Amino-7,8(6H)-Dihydropteridin-4-ones] / Armarego, Wilfred L.F. / Waring, Paul -- Some Simple s-Triazolopteridines / Brown, Desmond J. / Shinozuka, Kazuo -- Linear Tricyclic Analogs of Pteridines / Pendergast, William / Chan, Joseph H. -- Reactions of Furazano [3,4-djPyrimidines and their Application to Pteridine Synthesis / Boyle, Peter / Lockhart, Ronan -- Syntheses of some Blocked 7,8-Dihydropteridines / Cameron, Bobert C. / Lyall, William J.S. / Nicholson, Sidney H. / Bobinson, David H. / Suckling, Colin J. / Wood, Hamish C.S. -- Synthesis of Chiral Reduced Pteridine Coenzymes / Doyle, Paul M. / Szakolcai, Akos / Young, Douglas W. -- Report on Discussions / Benkovic, S. J. -- Chemical Aspects (2) -- Reactivity of Pteridines / Pfleiderer, Wolfgang / Baur, Ralph / Bartke, Michael / Lut, Hermann -- Synthesis and Antitumor Activity of 10-Deazaminopterins / DeGraw, J. I. / Brown, V. H. / Tagawa, H. / Kisliuk, R. L. / Gaumont, Y. / Sirotnak, F. M. -- Synthesis and Biological Activity of 5-Deazafolic Acid and 5-Deazaaminopterin / Taylor, Edward C. / Tseng, Chi-Ping / Harrington, Peter J. / Beardsley, G. Peter / Rosowsky, Andrew / Wick, Michael -- The Nor-Analogues of Folic Acid / Nair, M.G. / Rozmyslovicz, Mary K. / Kisliuk, R.L. / Gaumont, Y. / Sirotnak, F.M. -- Report on Discussions / Roth, B. -- Neurochemical and Clinical Aspects -- Metabolism of Pteridine Cofactors in Neurochemistry / Nichol, Charles A. / Viveros, O. Humberto / Duch, David S. / Abou-Donia, Martha M. / Smith, Gary K. -- Pteridines in Cancer and Other Diseases / Rokos, Katharina / Rokos, Hartmut / Frisius, Hildegard / Hüfner, Michael -- Dihydropteridine Reductase Activity in Human Breast Cancer. Studies of 580 Cases and Correlations with Hormone Receptors and Cellular Typing / Dhondt, Jean-Louis / Herlin, Christophe / Bonneterre, Jacques / Vie, M. Claude / Lefebvre, Jean / Demaille, Alain -- A Critical Appraisal of Methods for the Quantitative Analysis of Tetrahydrobiopterin, Dihydrobiopterin and Biopterin in Human Urine, Serum and CSE / Blair, J.A. / Whitburn, S.B. / Pheasant, ¿.E. / Leeming, R.J. / Morar, C. / Al-Beir, A. -- Inhibition of Pterin Biosynthesis in the Adrenergic Neuroblastoma N1E115 by Tetrahydrobiopterin and Folate / Kapatos, Gregory / Kaufman, Seymour -- Penetration of Reduced Pterins into Rat Brain: Effect on Biogenic Amine Synthesis / Levine, Robert A. / Lovenberg, Walter / Niederwieser, A. / Leimbacher, W. / Redweik, U. / Staudenmann, W. / Curtius, H.-Ch. -- Neopterin Deficiency (GTP Cyclohydrolase I Deficiency), a New Variant of Hyperphenylalaninemia / Niederwieser, A. / Staudenmann, W. / Wang, M. / Curtius, H.-Ch. / Atarés, M. / Cardesa-Garcia, J. -- Folate Pathways in Cells from Fragile X Syndrome Patients and Carriers / Erbe, Richard W. / Wang, Jin-Chen C. -- Report on Discussions / Cotton, R. G. H. -- Enzymology -- The Interaction of Substrates and Inhibitors with Dihydrofolate Reductase / Roberts, Gordon C.K. -- Catalytic Site of Dihydrofolate Reductase / Blakley, Raymond L. / Cocco, Lennie / Montgomery, John A. / Temple, Carroll / Roth, Barbara / Daluge, Susan / London, Robert E. -- Structure, Function and Affinity Labelling Studies of Dihydrofolate Reductase / Freisheim, J.H. / Susten, S. S. / Delcamp, T. J. / Rosowsky, A. / Wright, J. E. / Kempton, R. J. / Blankenship, D. T. / Smith, P. L. / Kumar, A .A. -- Methylene Tetrahydrofoíate Reductase: Studies in a Human Mutant and Mammalian Liver / Lewis, Garry P. / Rowe, Peter B. -- Studies on Methylenetetrahydrofolate Reductase from Pig Liver: Catalytic Mechanism and Regulation by Adenosylmethionine / Vanoni, Maria A. / Daubner, S. Colette / Ballou, David P. / Matthews, Rowena G. -- Role of Methylenetetrahydrofolic Acid Reductase in Regulation of Folic Acid Metabolism and its Relation to the Methyl Trap Hypothesis / Stokstad, E.L.R. / Chan, M.M-S. / Watson, J.E. -- The Mechanism of Action of the Transformylase Enzymes / Smith, Gary K. / Mueller, W. Thomas / Benkovic, Patricia A. / Slieker, Lawrence J. / DeBrosse, Charles W. / Benkovic, Stephen J. -- Folypolyglutamate Synthesis in Neurospora Crassa / Cossins, E.A. / Chan, P. Y. -- Report on Discussions / Baccanari, D. P. / Kuyper, L. F. -- Clinical Aspects: Cancer -- Folates and Cancer Chemotherapy / Bertino, J.R. / McGuire, J. J. -- Inability to Increase the Mobilisation of Liver Folates During Folate Deficiency Suggesting that this and Other Organs do not act as a Potential Folate Store for Marrow and Other Rapidly Proliferating Cells / Scott, J. M. / Molloy, A. / Smithwick, A. / McGing, P. / Weir, D. G. -- A High Molecular Weight Nonfunctional Immunoreactive Form of Dihydrofolate Reductase in L1210 Leukaemia Cells / Rothenberg, Sheldon / Iqbal, M. Perwaiz -- Further Characterization of the Pterdine Binding Variant of Alphas-Acid Glycoprotein, Accumulated in the Blood of Patients with Malignant Diseases / ¿ieger, Irmgard / Armarego, Wilfred L. F. / Fink, Michael -- Structure-Activity Relationships among 5-Substituted Lipophilic Diaminopyrimidine Antineoplastic Antifolates / Cody, Vivian / DeJarnette, Elaine / Zakrzewski, Sigmund F. -- Attempts to Design Inhibitors of Dihydrofolate Reductase Using Interactive Computer Graphics with Real Time Energy Calculations / Potterton, E. A. / Geddes, A. J. / North, A. C. T. -- Control of Methotrexate Polyglutamate Synthesis in Cultured Rat Hepatoma Cells / Galivan, John / Balinska, Malgorzata -- Differential Effects of Methotrexate or Fluorodeoxyuridine upon Mitochondrial and Cellular Nucleotide Pools / Bestwick, Richard K. / Moffett, Ginnie L. / Spiro, Craig / Mathews, Christopher K. -- Report on Discussions / Whiteley, J. M. -- Bioorganic Chemistry and Enzymology -- Chemical Mechanisms in the Action of Pteridine Coenzymes / Young, Douglas W. -- Irreversible Inactivation of Rat Liver Phenylalanine Hydroxylase by Reaction with (6S)-L-Erythro-Tetrahydrobiopterin / Parniak, Michael / Kaufman, Seymour -- p-Azidophenylalanine: A Potential Photoaffinity Probe for Rat-Liver Phenylalanine Hydroxylase / Webber, Stephanie / Whiteley, John M. -- Pyrimidine Models for the Cofactor of Phenylalanine Hydroxylase / Jongejan, J. A. / Mager, H. I. X. / Berends, W. -- Activation of Molecular Oxygen by Tetrahydropterin Monooxygenases / Ayling, June E. / Bailey, Steven W. -- Mechanistic Studies on Phenylalanine Hydroxylase: Structural Determination of the Tetrahydropterin Intermediates / Lazarus, Robert A. / DeBrosse, Charles W. / Benkovic, Stephen J. -- Properties of Thymidylate Synthase from Streptococcus Faecium / Kisliuk, R. L. / Rao, ¿. N. / Gaumont, Y. / Deschenes, R. / Vestal, K. / Karasik, M. / Maley, G. F. / Nair, M. G. / Baugh, C. M. -- Cloning the Gene for Eukaryotic C1-THF Synthase / Stäben, Chuck / Rabinowitz, Jesse C. -- Report on Discussions / Armarego, W. L. F. -- Biochemistry and Biology -- The Enzymatic Synthesis of the Drosopterins: Identification of a Pyrimidodiazepine as an Intermediate / Wiederrecht, Gregory J. / Paton, Duncan R. / Brown, Gene M. -- The Common Precursor of Sepiapterin and Drosopterin in Drosophila: Enzymatic and Chemical Synthesis / Hearl, W. G. / Dorsett, D. / Jacobson, K. Bruce -- The Common Precursor of Sepiapterin and Drosopterin in Drosophila: Enzymatic and Chemical Synthesis / Wächter, H. / Fuchs, D. / Hausen, ¿. / Reibnegger, G. -- The Role of Pteridines in Regulation of Growth / Klein Amy, Nancy / Miller, Jeffrey B. -- Evidence for a Folate Bound to Rat Hepatic Uroporphyrinogen III Cosynthase and its Role in the Biosynthesis of Heme / Piper, W. N. / Tse, J. / Clement, R. P. / Kohashi, M. -- Report on Discussions / Boyle, P. H. -- Presented Papers -- Aerobic Oxidation of 5,6,7,8-Tetrahydroneopterin / Armarego, Wilfred L. F. / Randies, David -- The Conformations of 7,8 (6H)-Dihydropterin Substrates and the Activity of Dihydropteridine Reductase (E.C.1.6.99.10) / Armarego, Wilfred L. F. / Waring, Paul -- Dihydrofolate Reductase: The Stereochemistry of Inhibitor Selectivity / Matthews, D. A. / Bolin, J. T. / Filman, D. J. / Volz, ¿. W. / Kraut, J. -- Synthesis of an 8-Deaza Analog of the Intermediate in the Thymidylate Synthetase Reaction (1) / Broom, Arthur D. / Srinivasan, Ananthachari -- The Synthesis of Analogs of Pteroylglatamyl-y-Phosphate as Potential Inhibitors of Folylpolyglutamate Synthetase / Tang, Kuo-Chang / Coward, James K. -- Synthesis and Activity of 8,10-Dideazaminopterin / DeGraw, J. I. / Kelly, L. F. / Kisliuk, R. L. / Gaumont, Y. / Sirotnak, F. M. -- CNDO/2 Molecular Orbital Calculations on the Antifolate DAMP and Some of its Analogues: Conformational Characteristics / Welsh, William J. / Mark, James E. / Cody, Vivian / Zakrzewski, Sigmund F. -- Fluorescent Analogues of Methotrexate as Probes for Folate Antagonist Molecular Receptors / Freisheim, J. H. / Kumar, A. A. / Black, A. M. / Anstead, G. M. / Kempton, R. J. / Susten, S. S. -- Dihydrofolate Reductase Overproduction Identified by Flow Cytometry Using a Fluorescent Methotrexate Analogue / Rosowsky, Andre / Wright, Joel E. / Beardsley, G. Peter / Shapiro, Howard M. -- New Syntheses and Transformations of Some Pteridines and Pteridine 3-Oxides / Kocevar, Marijan / Stanovnik, Branko / TiSler, Miha -- Photooxidation of Mercaptopteridines / Heckel, Armin / Pfleiderer, Wolfgang -- Reactivity of 6,7-Dichloro-1, 3-Dimethyllumazine / Abou-Hadeed, Khaled / Pfleiderer, Wolfgang -- Synthesis, Reactivity and Properties of 8-Substituted 2-Thio- and 2,4-Dithiolumazines / Hübsch, Walter / Pfleiderer, Wolfgang -- The Activity of Sulfonamide-Substituted Benzylpyrimidines Against Dihydropteroate Synthase, Dihydrofolate Reductase, and Bacterial Cell Cultures / Hyde, Richard M. / Paterson, Richard A. / Beddell, Christopher R. / Champness, John N. / Stammers, David K. / Baker, Dorothea J. / Goodford, Peter J. / Kuyper, Lee F. / Ferone, Robert / Roth, Barbara / Elwell, Lynn P. -- Structural Studies of Antifolate Drugs / Schwalbe, Carl H. / Cody, Vivian -- Isolation and Characterization of a Novel Folate Antagonist / Schlingraann, Gerhard / Stokstad, E. L. Robert -- Synthesis and Biological Properties of the S-8 Analog of 7,8-Dihydropteridinealcohol / Visser, K. / Seydel, J. K. -- Synthesis of Dihydrobiopterin from Dihydroneopterin Triphosphate in Rat Tissues and Human Blood Corpuscles: Diagnosis of Atypical Phenylketonuria due to Biopterin Deficiency by Assay of an Enzyme Involved in the Synthesis / Akino, Miki / Yoshioka, Shin'ichi / Masada, Masahiro / Inoue, Kayo / Yoshida, Takeo / Mizokami, Takashi / Matsuo, Nobutake -- Stereospecific Enzyme Mediated Syntheses of Tetrahydrofolate Derivatives / Bees, Lilias / Suckling, Colin J. / Talente, Edward / Wood, Hamish C. S. -- Immobilization of Dihydrofolate Reductase from Amethopterin Resistant Lactobacillus Casei / Ahmed, Faizy / Dunlap, R. Bruce -- X-Ray Studies of the Binding of Trimethoprim, Methotrexate, Pyrimethamine and Two Trimethoprim Analogues to Bacterial Dihydrofolate Reductase / Baker, D. J. / Beddell, C. R. / Champness, J. N. / Goodford, P. J. / Norrington, F. E. / Roth, B. / Stammers, D. K. -- A New Spectrophotometry Method for the Assessment of Tight Binding Benzyldiaminopyrimidine Inhibitors of Dihydrofolate Reductase / Dann, J. G. -- Two Interconverting Conformers of a Drug-Receptor Complex: The Lactobacillus Casei Dihydrofolate Reductase-NADP+ - Trimethoprim Complex / Bevan, A. W. / Birdsall, B. / Roberts, G. C. K. / Feeney, J. / Gronenborn, A. / Clore, G. M. / Burgen, A. S. V. -- Multiple Conformations of the Dihydrofolate Reductase- Folate-NADP+ Complex / Birdsall, B. / Gronenborn, A. / Clore, G. M. / Hyde, E. I. / Roberts, G. C. K. / Feeney, J. / Burge, A. S. V. -- The Three-Dimensional Structure of Mouse L1210 Dihydrofolate Reductase / Stammers, D. K. / Champness, J. ¿. / Dann, J. G. / Beddell, C. R. -- Isolation and Amino Acid Sequence Studies of Dihydrofolate Reductase from Neisseria Gonorrhoeae / Stone, D. / Paterson, S. J. / Tansik, R. / Baccanari, D. P. -- Purification of 7,8-Dihydropteroate-Synthetase from E. Coli by Affinity- and Hydrophobic Interaction Chromatography / Bartels, Rainer / Bock, Lothar -- Isolation and Characterization of an E. Coli Mutant Affected in Dihydrofolate- and Folylpolyglutamate- Synthetase / Ferone, R. / Singer, S. C. / Hanlon, M. H. / Roland, S. -- Purification and Properties of 5-Formyltetrahydrofolate Cyclodehydrase from Rabbit Liver / Schirch, LaVerne / Hopkins, Sam -- Structural Studies on Formyl-Methenyl-Methylene Tetrahydrofolate Synthetase from Rabbit Liver / Peterson, Darrell / Schirch, LaVerne -- Utilization of Folate Polyglutamate for Growth by Lactobacillus Casei / Maclntyre, Mary-Frances / Cooper, Bernard A. / Lue-Shing, Helena -- Folate and Folate Enzymes as Structural Components of Bacteriophage Particles / Kozloff, L. M. / Sadewasser, D. / Lute, M. -- Studies on the Substrate Specificity of Mammalian Folylpolyglutamate Synthetase / McGuire, J. J. / Hsieh, P. / Bertino, J. R. / Coward, J. ¿. -- Properties of Corynebacterium Species Dihydrofolate Synthetase-Folylpolyglutamate Synthetase / Shane, Barry -- Purification and Characterization of Folylpolyglutamate Synthetase from Lactobacillus Casei and Hog Liver / Bognar, Andrew L. / Cichowiez, David J. / Shane, Barry -- The Molybdenum Cofactor from Xanthine Oxidase: Quantitative Assay of the Molybdenum Cofactor by Activation of Nitrate Reductase Activity in Extracts of the Nit-1 Mutant of Neurospora crassa / Hawkes, Timothy R. / Bray, Robert C. -- Structural Studies of Calf Thymus Thymidylate Synthase / Dwivedi, Chandra M. / Kisliuk, Roy L. / Maley, Gladys F. -- A Comparison of the T-Even Phage Induced and Escherichia Coli Thymidylate Synthases / Maley, Gladys F. / Beifort, Marlene / Maley, Frank -- Thermophilicity of Dihydrofolate Reductase and Thymidylate Synthetase from a Thermophilic Microorganism / Mandelbaum-Shavit, Frederika / Reizer, Jonathan / Grossowicz, Nathan -- Chemical Characterization of Two Folate-Binding Proteins from Mitochondria: Dimethylglycine Dehydrogenase and Sarcosine Dehydrogenase / Cook, Robert J. / Wagner, Conrad -- Allosteric Mung Bean (Vigna radiata) Serine Hydroxylmethyl-Transferase / Narasimha Rao, D. / Appaji Rao, N. -- Comparative Study of the Eye Colour Mutants of Drosophila Melanogaster: Quantification of the Eye-Pigments and Related Metabolites / Ferré, Juan / Silva, Francisco / Dolores Real, Maria / Ménsua, José Luis -- Studies on Sepialumazine, the Characteristic Larval Integument Pigment of the Bombyx Mori Kiuki Mutant / Tsusue, Motoo / Mazda, Toshio / Sakate, Sakae -- Macromolecular Regulation of Sepiapterin and Drosopterin Synthesis in the Purple Mutant of Drosophila / Jacobson, K. Bruce / Yim, John J. / Wobbe, C. R. -- The Hydroxylation of Phenylpropanoids by Euglena gracilis : Role of Pteridines / Fink, Rita / Paur, Eva / Elstner -- Studies with Old Yellow Enzyme, Reconstitution with Lumazine Analogs as Coenzyme / Wetzel, GUnter / Ghisla, Sandro -- Biosynthesis of Riboflavin / Bacher, Adelbert / Le Van, Quang / Bühler, Matthias / Keller, Paul J. / Floss, Heinz G. -- Biosynthesis of Riboflavin / Nielsen, Peter / Bacher, Adelbert -- Metabolism and Function of Pterin Compounds in Seed Germination / Kohashi, Masahiro / Tornita, Kazuhiro / Iwai, Kazuo -- Thymidylate Synthetase During Proliferation and Differentiation of Physarum polycephalum / Gröbner, Peter / Loidl, Peter -- Influence of Vitamin B12 on Folate Metabolism in Lactobacillus Leichmannii / Nair, C. P. P. / Noronha, J. M. -- High-Affinity Binding of Folate to a Small and Large Molecular Size Protein from Human Milk / Hansen, Steen Ingemann / Holm, Jan / Lyngbye, J¿rgen -- High-Affinity Folate Binding in Leukocytes from Normal Subjects Displays Positive Cooperativity, and the Affinity Depends on the Protein Concentration / Holm, Jan / Hansen, Steen Ingemann / Lyngbye, J¿rgen -- Characteristics of 5-Methyltetrahydrofolate Binding to the Folate-Binding Protein from Cow's Whey / Lyngbye, J¿rgen / Hansen, Steen Ingemann / Holm, Jan -- Interactions of Folate-Dependent Enzymes of DNA Precursor Metabolism in T4 Phage-Infected Bacteria / Allen, J. R. / Booth, Joseph W. / Goldman, Daniel A. / Lasser, Gerald W. / Purohit, Sarla / Sargent, R. Geoffrey / Mathews, Christopher K. -- The Regulation of Biopterin Biosynthesis in the Rat / Milstien, S. / Kaufman, S. -- Biosynthesis of Tetrahydrobiopterin in Mammalian Tissues by De Novo and Salvage Pathways / Nichol, Charles A. / Smith, Gary K. / Duch, David S. -- Perspectives on Tetrahydrobiopterin Biosynthesis in Mammals / Curtius, H.-Ch. / Häusermann, M. / Heintel, D. / Niederwieser, A. / Levine, Robert A. -- Human Dihydropteridine Reductase (DHPR) Deficiency / Firgaira, Frank A. / Cotton, Richard G.H. / Danks, David M. -- Coordinate Regulation of Guanosine Triphosphate Cyclohydrolase and Tetrahydrobiopterin in Adrenal Medullary Chromaffin Cells / Abou-Donia, M. M. / Daniels, A. J. / Wilson, S. P. / Nichol, C. A. / Viveros, O. H. -- Regulation of Adrenocortical Guanosine Triphosphate Cyclohydrolase and Tetrahydrobiopterin in Normal and Spontaneously Hypertensive Rats / Abou-Donia, Martha M. / Daniels, Alejandro J. / Nichol, Charles A. / Viveros, O. Humberto -- Inhibition of Brain Sepiapterin Reductase by a Catecholamine and an Indoleamine / Katoh, S. / Sueoka, T. / Yamada, S. -- Mouse Mastocytoma Tryptophan Hydroxylase: Role of Iron and Catalase in the Expression of Enzyme Activity after Activation by Anaerobic Preincubation with Dithiothreitol / Hasegawa, Hiroyuki / Yanagisawa, Mariko / Inoue, Fumio / Ichiyama, Arata -- Folic Acid Induced Kindling in Rats: Changes in Brain Amino Acids / O'Donnell, R.A. / Leach, M.J. / Miller, A. A. -- Impaired Pteroylpolyglutamate Synthesis in the Cobalamin-Inactivated Rat / Perry, Janet / Chanarin, I. / Deacon, Rosemary / Lumb, M. -- A Radioimmunoassay for Determination of D-Erythro- Neopterin / Rokos, Hartmut / Rokos, Katharina -- Radioimmunoassay for Neopterin in Body Fluid and Tissues / Nagatsu, Toshiharu / Sawada, Makoto / Yamaguchi, Tokio / Sugimoto, Takashi / Matsuura, Sadao / Akino, Miki / Nakazawa, Nobuhiko / Ogawa, Hiroshi -- A Specific Antiserum Against Tetrahydrobiopterin: Its Preparation and Application to Immunohistochemistry / Matsuura, Sadao / Sugimoto, Takashi / Nagatsu, Ikuko / Yamaguchi, Tokio / Nagatsu, Toshiharu -- Speculation on the Mechanism of Therapeutic Action of Tetrahydrobiopterin in Human Disease / Levine, Robert A. / Lovenberg, Walter / Curtius, H.-Ch. / Niederwieser, A. -- Correlation of Tetrahydrobiopterin Content and Guanosine Triphosphate Cyclohydrolase Activity in Cells and Tissues / Duch, David S. / Nichol, Charles A. -- Unconjugated Pteridines in Human Physiological Fluids. Normal and Pathological Profiles / Dhondt, J.-L. / Bellahsene, Z. / Largilliere, C. / Bonneterre, J. / Vanhille, P. / Noel, C. / Choteau, P. / Farriaux, J. P. -- Biopterin and Phenylalanine Metabolism During Early Liver Regeneration / Dhondt, Jean-Louis / Kapatos, Gregory / Parniak, Michael / Wilgus, Harvey / Kaufman, Seymour -- GTP-Cyclohydrolase Activities in Rat Liver / Dhondt, Jean-Louis / Bellahsene, Zina / Farriaux, Jean-Pierre / Dautrevaux, Michel -- Phenylalanine Hydroxylase Assay Using Biopterin and Synthetic Pteridine / Berry, Helen K. / Hsieh, Monica -- Dihydropteridine Reductase Levels in Human Normal and Neoplastic Tissues / Eggar, C. / Barford, P.A. / Blair, J. A. / Pheasant, A. E. / Guest, A. E. / Oates, G. D. -- Investigations of Tissue Folates in Normal and Malignant Tissues / Pheasant, A. E. / Bates, J. / Blair, J. A. / Nayyir-Mazhir, R. -- Blood Cell Biopterin as an Indicator of Transplanation- Induced Hemopoiesis and Leukemic Cell Proliferation / Fink, Michael / Ziegler, Irmgard / Kölb, Hans-Jochen / Bodenberger, Ulrich / Wilmanns, Wolfgang -- Assessment of Urinary Neopterin in the Early Diagnosis of Human Allograft Rejection / Fuchs, D. / Hausen, ¿. / Reibnegger, G. / Wächter, H. / Huber, Ch. / Margreiter, R. / Spielberger, M. -- Behaviour of Neopterin Levels in Patients with Haematological and Gynaecological Neoplasms / Reibnegger, G. / Fuchs, D. / Hausen, A. / Wächter, H. -- Pteridines in Dictyostelium discoideum and Physarum polycephalum / Loidl, Peter / Fuchs, Dietmar / Gröbner, Peter / Hausen, Arno / Reibnegger, Gilbert / Wächter, Helmut / Schweiger, Manfred / Gerisch, Günther -- Biochemical and Chemotherapy Studies on BW 301U, a Novel Lipophilic 2,4-Diaminopyridopyrimidine Antifolate / Duch, David S. / Nichol, Charles A. -- Toxicity of a Series of Antifolate Compounds in a Methotrexate-Resistant Celi Line / Hamrell, Michael R. -- Interaction of Methotrexate Poly(L-Lysine) with Transformed Hepatic Cells in Culture / Whiteley, John M. / Galivan, John / Balinska, Malgorzata -- A Novel Technique for Producing Folate-Deficient Hepatica Cells / Balinska, Malgorzata / Samsonoff, William / Galivan, John -- Methotrexate Metabolism in Acute Lymphoblastic Leukemia / Whitehead, V. Michael / Rosenblatt, David S. -- Altered Methotrexate Sensitivity in Human Leukemic K562 Amino Acid Transport Mutant Cells / Scanlon, Kevin J. / Riegelhaupt, Rona / Pallai, Michele / Kisthard, Holly / Kassan, Sharon / Waxman, Samuel -- Methotrexate and Methotrexate Polyglutamates in Erythrocytes After High-Dose Methotrexate / Schalhorn, Andreas / Sauer, Hansjörg / Wilmanns, Wolfgang / Stupp-Poutot, Gabriele -- Methotrexate Polyglutamates in Human Fibroblasts: Reversal of Antifolate Cytotoxicity / Rosenblatt, David S. / Whitehead, V. Michael -- Human Cells Resistant to Methotrexate: Cross Resistance and Collateral Sensitivity to the Nonclassical Antifolates Trimetrexate, Metoprine, Homofolic Acid and CB3717 / Diddens, Heyke / Niethammer, Dietrich / Jackson, Robert C. -- Homology of Two Forms of Dihydrofolate Reductase in Human Leukaemic and L1210 Cells During Expression of Resistance to Methotrexate / Lamey, Philip / Harding, Nigel / Dow, Jocelyn -- Adaptation of Folylpolyglutamates to Folate Deprivation in Mouse Hepatoma Cells / Priest, D. G. / Doig, M. T. / Mangum, M. -- Utilization and Loss of Reduced Folates by Human Fibroblasts in Vitro / Hilton, Jack H. / Cooper, Bernard A. / Rosenblatt, David S. / Lue-Shing, Helena -- Factors Affecting Folate Polyglutamate Biosynthesis in Rat Liver / Keating, S. / Weir, D. G. / Scott, J. M. -- Differential Binding of Folates but not Methotrexate (MTX) by Brush Border (BB) and Basal Lateral (BL) Membranes of Rat Renal Cortex / Corrocher, Roberto / Abramson, R. G. / King, F. V. / Schreiber, C. / Waxman, S. -- Biosynthesis of Folate Derivatives in Ehrlich Ascites Carcinoma Cells Grown in Mice and in some Organs of the Host / Sikora, Ewa / Grzelakowska-Sztabert, Barbara -- Variability of Thymidylate Synthetase in Ehrlich Carcinoma Cells and its Role in Resistance to 5-Fluorodeoxyuridine / Jastreboff, Malgorzata / Kfdzierska, Barbara / Rode, Wojciech -- One-Carbon Metabolism in Human Lymphocytes / Rowe, P. B. / McCairns, E. / Sauer, D. / Craig, G. -- Possible Mechanisms of Folate Catabolism / Pheasant, A. E. / Blair, J. A. / Saleh, A. M. / Guest, A. E. / Barford, P. A. / Choolun, R. / Allan, R. N. -- The Intracellular Folate Pool: Studies of Kinetics and Functional Significance / Steinberg, Stephen / Fonda, Susan / Campbell, Caryl L. / Hillman, Robert S. -- Intestinal Folate Transport. A pH-Dependent, Carrier- Mediated Process / Strum, Williamson B. / Said, Hamid M. -- Effects of Folate Depletion on Growth and Survival of Human Cell Line K-562 in Culture / Watkins, David / Shapiro, Thomas E. / Cooper, Bernard A. -- Alterations in Folate Metabolism of the Rat Induced by Acute Ethanol Administration / McMartin, Kenneth E. / Collins, Timothy D. -- Participation of Pterins in the Control of Lymphocyte Transformation and Lymphoblast Proliferation / ¿¡eger, Irmgard / Ham, Ulrike / Berndt, Jürgen -- The Pterin Component of the Molybdenum Cofactor (Molybdopterin): Relationship to Urothione / Johnson, Jean L. / Hainline, Bryan E. / Rajagopalan, ¿. V. -- Report on Presented Papers / Suckling, C. J. / Scott, J. M. -- Author Index -- Subject Index -- Backmatter