Solid Dispersion of Dronedarone HCl for Better Dissolution Profile

von Subhashis Debnath

Softcover - 9786202515207

39,90 €

Versandkostenfrei

Auf meine Merkliste

Hinweis: Print on Demand. Lieferbar in 2 Tagen.

Lieferzeit nach Versand: ca. 1-2 Tage
inkl. MwSt. & Versandkosten (innerhalb Deutschlands)

Autorenfreundlich Bücher kaufen?!

Beschreibung

Dronedarone is the class III anti arrhythmatic drug of benzofuron derivative having high lipophilicity and less aqueous solubility and less dissolution rate. The bioavailability (absolute) of the drug in absence of food is reported as low which is nearly 4%. The presence of fatty meal increases the bioavailability of dronedarone to nearly about 15%. Thus in this research work a solid dispersion formulation is tried which enhances the oral bioavailability and Dissolution profile of the poorly aqueous soluble Dronedarone HCl.