Smart Polymeric Chitosan Derivatives for Human Genomic Material

Smart polymers are polymers that respond to very slight changes accompanying with relatively large phase or property changes within different physical or chemical conditions. They become increasingly more common due to their chemistry and induced conformational changes in polymer structures and devise ways that sense specific environmental changes in biological systems. Chitosan is one of the natural and biodegradable polymers that attracted important interest because of its various proposed new applications, consisting of pharmaceutical and biomedical engineering, especially used in drug and gene delivery. In this context, chitosan derivatives were prepared and their effect on the human genetic material, DNA, was assessed by Nanodrop UV-spectroscopy and Agarose Gel Electrophoresis methods. The results revealed that all types of the studied chitosan derivatives have a safety effect on the DNA, and binding with it.