Simultaneous estimation of combination tablet dosage form by HPLC

The new products which are coming up by certain pharmaceutical companies are in combination of different drugs, rather than a single drug alone. These drug combinations have a wider range to treat as compared to single drug component. Hence Quantitative analysis of multicomponent formulations usually requires a prior separation of drugs from the excipients or elaborate separation procedures for multiple drugs themselves. Regardless of the various pharmaceutical and reported methods available, development of a simple and systematic procedure that given as clear separation of drugs is a difficult endeavor. The presence of additives and decomposition products further complicates the development of analytical procedures. As a result, simple, rapid and economical methods for the simultaneous analysis of multicomponent formulation, which don't require extraction or separation of the analyte from themselves or from the excipients, becomes necessary for the pharmaceutical industry.