Serum uric acid as a plausible biomarker and its role as a scavenger in Parkinson's disease

Research Paper (postgraduate) from the year 2023 in the subject Biology - Neurobiology, , language: English, abstract: Serum uric acid is a promptly affirmed neuroprotective agent. Its concentration levels in Parkinson¿s disease (PD) were found to be an efficient diagnostic biomolecule. Although it is able to minimize PD associated disability and symptoms worsening by preventing the formation of reactive oxygen species, Lewy bodies, abnormal proteins and intracellular stress. Bowel bladder, swallowing, speech, memory and sleep disorders are some of the non-motor symptoms of Parkinson¿s disease. Its motor symptoms include tremors, muscular rigidity, cramps, gait and body balance disturbances. Geriatric studies consider Parkinson as second most worldwide prevailing disorder associated with body shaking syndrome accompanied by dopamine deficits, generation and accumulation of brain damaging proteins, ROS and other metabolites. Uric acid is a devouerer of free oxygen, hydroxyl radicals and superoxide dimutase additionally it chelates the Ferric molecules to diminish its negative effects in PD brain. Measurement of serum uric acid is a potent biomarker for several brain degenerating diseases, particularly Parkinsonism, whilst its increased serum extent regulates the brain protective mechanism especially by reducing harmful oxidation.