Screening of anti gout activity in Bryophyllum calycinum leaves

The present study has been conducted to evaluate antigout activity of aqueous and alcoholic extracts of Bryophyllum calycinum leaves on potassium oxonate-induced gout rat model.The study was conducted on Sprague-Dawely rats dividing them in eight groups having six rats in each group. Rats were fasted for 16 hr. before potassium oxonate injection. After 1 hr. of Oxonate injection, blood samples were collected for parameter evaluation for control group. Allopurinol was given to the standard group and different test extract, each extract with three different doses i.e. 100, 150, 200 mg/kg were given to treated groups for consecutive 5 days. Blood samples were taken on 5th day for evaluation of anti gout activity of test extracts of Bryophyllum. Results for parameter evaluated for treated groups were compared with standard group.At the end of study,Gouty rats treated with aqueous and alcoholic extracts of Bryophyllum calycinum at 200 and 400 mg/kg body weight and standard treatment allopurinol at 5 mg/kg body weight showed reduction in platelets counts, serum creatinine, uric acid, BUN, and XO enzyme level.Oral administration of aqueous and alcoholic extracts of Bryophyllum calycinum.