Role of Early Second Trimester

High Sensitivity C - Reactive Protein for Prediction of Adverse Pregnancy Outcome. Pregnancy, childbirth and their consequences are still the leading cause of disease, disability and death amongst women of reproductive age in developing countries. Over 300 millions in the developing world suffer from short term or long term illness brought about by pregnancy and childbirth; 5, 29,000 die each year. India is amongst those countries which have a very high Maternal Mortality Rate.While most pregnancies are problem free, few will have complications, minor to very serious. Human pregnancies are associated with profound inflammatory changes during early phase (Hwang HS et al 2007) resulting in adverse pregnancy outcome like premature rupture of membrane, hypertensive disorders of pregnancy, gestational diabetes mellitus, preterm labour, low birth weight baby and still birth. Attempts are being made continuously for having screening tests with high sensitivity and positive predictive value so that timely preventive prophylactic therapies can be tried to avoid such pregnancy complications.