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Beschreibung
When compared to MTA cells, MTB-01 cells were susceptible to risedronateinduced apoptosis, had decreased ability to bind to risedronate-treated bone, and did not produce MMP-2 or MMP-9 proteases. MTA cells were less susceptible to risedronateinduced apoptosis and produced MMP-2. Additionally, adhesion of MTA cells to bone matrix was not diminished by risedronate treatment. Our results suggest that the nonresponsive nature of the MTA cell line may be due to MMP-2 production (possibly allowing ongoing destruction of risedronate-treated bone), continued adhesion to risedronate-treated bone matrix, and decreased susceptibility to risedronate-induced apoptosis.
Comparison of Effects of Risedronate on Bone Metastasis of Two Malignant Rat Mammary Tumor Cell Lines, MTA & MTB-01
Details
| Verlag | LAP LAMBERT Academic Publishing |
| Ersterscheinung | 03. Februar 2012 |
| Maße | 22 cm x 15 cm x 0.9 cm |
| Gewicht | 209 Gramm |
| Format | Softcover |
| ISBN-13 | 9783847341529 |
| Seiten | 128 |
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