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Beschreibung
Aging can be viewed partly as a degenerative process dictated by free radical reactions. Human diploid fibroblasts (HDFs) lose the capacity to proliferate and enter a state termed replicative senescence after a finite number of population doublings in vitro. Presenescent human fibroblasts, when treated with a sub-lethal dose of H2O2, enter long term growth arrest resembling replicative senescence. H2O2 induced growth arrest; p53 protein expression and the effect of vitamin C as an antioxidant were determined in this study.
A study to investigate the replicative cessation, morphology and DNA damage in human fibroblasts under stress conditions
Details
| Verlag | LAP LAMBERT Academic Publishing |
| Ersterscheinung | 02. Dezember 2011 |
| Maße | 22 cm x 15 cm x 1.3 cm |
| Gewicht | 322 Gramm |
| Format | Softcover |
| ISBN-13 | 9783846553268 |
| Seiten | 204 |
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