Quantum Dot Peptide Nanobioassembly for Biosensing

This book describes the architecture of quantum dot peptide nanoassembly, its molecular photonics and optoelectronics properties for biosensing as well as cancer cell imaging. The objective in the research consist of three parts 1) bioconjugation of quantum dots (QDs) with non fluorescent black hole quencher-1(BHQ-1) molecule to construct a nanobioassembly and the formation of an array of large number nanobioassembly on a mesoporous silica nanoparticle surface 2) Establishment of F¿rster resonance energy transfer (FRET) signal transduction between QD donor and BHQ-1 acceptor by bridging the two through a matrix metalloproteinase-2 (MMP-2) targeting short peptide. 3) Sensing the MMP-2 presence in solution as well as cancer cells extra cellular matrix (ECM).