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Beschreibung
This book contains both review and synthesis of new pyrazolo[3,4-d]pyrimidine derivatives as cycline dependent kinase inhibitors (CDKIs). Moreover, cytotoxic activity for the newly synthesized compounds were evaluated, specially on breast cancer cell line (MCF-7). The results obtained were compared with methotrexate as a reference drug. Docking study and molecular modeling were also done using MOE program. I hope this work to be helpful and a starting point for much more new compounds with better activity to help in treatment of such a big terrible disease like cancer. Author: Phoebe F. Lamie
Details
| Verlag | LAP LAMBERT Academic Publishing |
| Ersterscheinung | 26. Februar 2016 |
| Maße | 22 cm x 15 cm x 1.6 cm |
| Gewicht | 387 Gramm |
| Format | Softcover |
| ISBN-13 | 9783659792991 |
| Seiten | 248 |