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Pyrazolopyrimidine derivatives as cyclin-dependant kinase inhibitors

Pyrazolopyrimidine derivatives as cyclin-dependant kinase inhibitors

von Phoebe F. Lamie
Softcover - 9783659792991
76,90 €
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Beschreibung

This book contains both review and synthesis of new pyrazolo[3,4-d]pyrimidine derivatives as cycline dependent kinase inhibitors (CDKIs). Moreover, cytotoxic activity for the newly synthesized compounds were evaluated, specially on breast cancer cell line (MCF-7). The results obtained were compared with methotrexate as a reference drug. Docking study and molecular modeling were also done using MOE program. I hope this work to be helpful and a starting point for much more new compounds with better activity to help in treatment of such a big terrible disease like cancer. Author: Phoebe F. Lamie

Details

Verlag LAP LAMBERT Academic Publishing
Ersterscheinung 26. Februar 2016
Maße 22 cm x 15 cm x 1.6 cm
Gewicht 387 Gramm
Format Softcover
ISBN-13 9783659792991
Seiten 248

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