Prediabetes and Hepatitis

Prevalence has increased world wide and experts have projected that more than 470 million will be predictable by 2030 (1). Prediabetes has been associated with simultaneous presence of insulin resistance and abnormalities or dysfunction of beta cells, which are evident before glucose initiates its rise in the blood.Evidence has shown the association between prediabetes and early forms of nephropathy, chronic kidney disease, small fiber neuropathy, retinopathy and increased macrovascular disease. For prediabetic individuals, lifestyle modification is the cornerstone with evidence of relative risk reduction of 40-70%.The objective of present communication is to evaluate the association between HCV infection, measured as positivity to anti-HCV antibodies, and the incidence of prediabetes in a cohort of subjects sampled from the Mexican Diabetes Prevention (MexDiab) Study. HCV infection resembles nonalcoholic steatohepatitis (NASH) in numerous features, such as the presence of steatosis, serum dyslipidemia, and oxidative stress in the liver.