Physiology of primary hemostasis from A to Z

Primary hemostasis represents all phenomena that lead to the initial closure of a ruptured blood vessel by the formation of a clot consisting essentially of platelets. The vascular endothelium is a thromboresistance surface. Vascular endothelium lesion will lead to vasoconstriction. Thus, platelets will come in contact with subendothelial thrombogenic components. Currently, knowledge of this process at the biochemical, pharmacological, and even molecular levels is very accurate. It aids in the diagnosis of diseases due to the impairment of one or more stages of primary hemostasis. Therefore, the support is more appropriate. However, a certain number of disorders still elude a precise diagnosis, justifying the continuation of the studies at a physiological or pathophysiological level. Hence, the analysis of such abnormalities may lead to major advances in understanding platelet pathology.