Oxidative Stress and Antioxidant therapies for Rheumatoid Arthritis

The autoimmune disease rheumatoid arthritis is typified by systemic inflammation of the synovial joints. Reactive oxygen species (ROS) and activated phagocytic cells are produced by oxygen metabolism, which has a significant impact on the pathophysiology of RA. In the case of RA, the sequence of oxidative processes is crucial. Superoxide anions, hydrogen peroxide, hydroxyl radicals, nitric oxide, and hypochlorous acid are examples of reactive ions that are advancing the cause. These RNS and ROS species set up a series of events that disrupt the immune system's overall function and genetic integrity, ultimately leading to RA. Review the literature on the specific roles played by oxidant molecules in the pathophysiology of RA as well as the functions of various antioxidants in reducing these stressors.