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Oral Bioavailability Improvement by P-Glycoprotein Modulation

Oral Bioavailability Improvement by P-Glycoprotein Modulation

von Lalit Mohan Negi, Sushama Talegaonkar und Tahrun Nisha
Softcover - 9783659432521
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Beschreibung

Oral delivery of chemotherapeutic agents still remains a challenging area as most of the chemotherapeutic agents are either not bioavailable or have very low bioavailabilty due to their poor solubility, stability and permeability. It has been found that the orally administered anticancer drugs would be eliminated either by metabolic enzymes like cytochrome P450 or by the efflux transporters like P-gp. Hence the present study is aimed to develop a dual loaded microparticulate system (Drug and P-gp herbal modulator) to enhance the bioavailability of the selected anticancer agent by P-gp modulation.

Dual loaded particulate drug carriers for anticancer drugs

Details

Verlag LAP LAMBERT Academic Publishing
Ersterscheinung 08. April 2015
Maße 22 cm x 15 cm x 0.9 cm
Gewicht 227 Gramm
Format Softcover
ISBN-13 9783659432521
Seiten 140

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