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Novel Synthetic Chemistry of Ureas and Amides

von Marc Hutchby
Softcover - 9783642448904
106,99 €
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Hardcover - 9783642320507
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Beschreibung

In this thesis, the author investigates the chemistry and application of molecules containing urea and amide bonds. These bonds are some of the strongest known and are fundamental to biological processes. The author describes his discovery that sterically hindered ureas undergo solvolysis at room temperature under neutral conditions. This is a remarkable finding, since ureas are inert under these conditions and a general rule of chemistry is that hindered substrates are less reactive. Remarkably, the author translates these results to the correspondingly sterically hindered amides. This thesis has resulted in a number of outstanding publications in high profile journals. The unique method for breaking urea and amide bonds developed in this study is likely to have far reaching consequences for biological protein manipulation.

Details

Verlag Springer Berlin
Ersterscheinung 20. September 2014
Maße 23.5 cm x 15.5 cm
Gewicht 289 Gramm
Format Softcover
ISBN-13 9783642448904
Auflage 2013
Seiten 166

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