Novel Drug Delivery Technologies for Vaginal Afflictions

Efficient drug delivery at vaginal cavity is often a challenge owing to its peculiar physiological variations including vast differences in pH. Keeping in view this attribute of the target site, the current work was aimed at developing formulation strategies which could overcome this and successfully deliver molecule like Itraconazole through different novel formulation technologies. When evaluated in vivo, these did not exhibit any irritation potential despite appreciable bioadhesion. A remarkable decrease in CFUs was also observed when evaluated in rat infection model. Thus, the proposed study defines the challenges for developing suitable formulation systems overcoming the delivery barriers of the site.