Neutrophil dysfunction in periodontal diseases

Periodontitis is a chronic inflammatory disease that results from a complexpolymicrobial infection, leading to tissue destruction. The inflammatory process is regulated by an orchestrated network of cytokines and chernoktnes. The host response to the bacterial challenge originating from the dental biofilm has been considered to play a major role on both initiation of the disease and on the tissue destruction associated with its progress. Furthermore, evidences indicate that the adaptive immune responses, including humoral and cellular aspects, are fundamentally important in mediating the host response to microorganisms of oral biofilm and also in tissue destruction associated with periodontal disease.