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Beschreibung
Four GDNF ligands (GDNF, neurturin, artemin and persephin), and mesencephalic astrocyte-derived neurotrophic factor (MANF) and conserved dopamine neurotrophic factor (CDNF) protect midbrain dopaminergic neurons that degenerate in Parkinson''s disease. Each GDNF ligand binds a specific coreceptor GDNF family receptor ¿ (GFR¿), leading to the formation of a heterotetramer complex, which then interacts with receptor tyrosine kinase RET, the signalling receptor. The present work describes the structural and biochemical characterization of the GDNF-GFR¿1 complex and the MANF and CDNF proteins.
The structural and functional studies of GDNF and MANF/CDNF family of neurotrophic factors
Details
| Verlag | LAP LAMBERT Academic Publishing |
| Ersterscheinung | 13. September 2010 |
| Maße | 22 cm x 15 cm x 0.6 cm |
| Gewicht | 155 Gramm |
| Format | Softcover |
| ISBN-13 | 9783838322469 |
| Seiten | 92 |
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