Nanostructured lipid carriers

The objective was to formulate Silymarin into nanostructured lipid carriers (NLC) to enhance its sun screening efficacy and safety. NLC of Silymarin were prepared by the high pressure homogenization. The study design involves the investigation of the effect of two independent variables namely ratio of solid lipid and liquid lipid concentration (60:40, 70:30, 80:20 with respect to total lipid), and Tween 80 concentration (3%, 4% and 5%) on Surface morphology by SEM analysis, FTIR, DSC, particle size (PS), entrapment efficiency (%EE) and in-vitro drug release after 24 h. The prepared NLC were spherical in overall shape. Solid lipid and liquid ratio 70:30 and Tween 80 concentration 5% were found to significantly decrease the PS and increase the EE% with when used ethyl oleate concentration 30% (of total lipid concentration). Increasing Tween 80 concentration decreased significantly the particle size. But showing slightly effect on the %EE. Silymarin-loaded NLC dispersion was then formulated into gel. The incorporation of Silymarin into NLC greatly increased the in vitro sun protection factor SPF of formulation optimized batch A6 was 37.14 and 21.72 of marketed formulation.