Nanosponges: As a Transdermal Drug Delivery System

The aim and objective of the study was to formulate and evaluate Flurbiprofen nanosponges for topical delivery. Nanosponges were prepared using ethyl cellulose as the polymer and polyvinyl alcohol as the stabilizing agent by a solvent evaporation method. The Nanosponges prepared were evaluated for different parameters like the drug: polymer ratio, stirring speed, and time. The encapsulation and the diffusion study of the formulation were done. Particle size analysis and scanning electron microscopy of the nanosponges were performed and from this study, it was found that the nanosponges were spherical in shape and have a porous nature. The nanosponges prepared were incorporated into the gel base of carbapol. In diffusion study of the nanosponge, the gel was performed.