This textbook provides a comprehensive monography on multiple system atrophy (MSA), a rare and fatal neurodegenerative disorder that presents with autonomic failure and either parkinsonism (MSA-P) or cerebellar ataxia (MSA-C).The underlying neuropathology of MSA is characterized by striatonigral degeneration (SND), olivopontocerebellar atrophy (OPCA) and unique oligodendroglial cytoplasmic alpha-synuclein inclusions. MSA is therefore classified among the alpha-synucleinopathies such as Parkinson`s disease, pure autonomic failure and dementia with Lewy bodies. Over the last decade there have been important advances in early diagnosis, pathogenesis research and clinical trial activity. The monography will cover the entire spectrum ranging from molecular and genetic work to symptomatic and interventional therapies. The book is written for movement disorder clinicians and basic neuroscientists interested in degenerative movement disorders.
Tags: Medizin, Klinische Fächer
Hardcover - 9783709106860 Verlag: Springer-Verlag KG Ersterscheinung: November 2013 ISBN-13: 9783709106860 Größe: 242 mm x 159 mm x 20 mm Gewicht: 448 Gramm 198 Seiten
Taschenbuch - 9783709120101 Auflage: Softcover reprint of the original 1st ed. 2014 Verlag: Springer Vienna Ersterscheinung: August 2016 ISBN-13: 9783709120101 Größe: 235 mm x 155 mm x 11 mm Gewicht: 334 Gramm 216 Seiten Versandfertig in 3-5 Tagen.