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MTHFR gene polymorphisms and risk of male infertility

MTHFR gene polymorphisms and risk of male infertility

von Noor Ullah und Saima Siddiqi
Softcover - 9786139576210
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Beschreibung

The A1298C and C665T polymorphisms of methylenetetrahydrofolate reductase (MTHFR) gene have previously been reported to be associated with male infertility in various populations. Methylenetetrahydrofolate reductase (MTHFR) is one of the key controlling gene intricated in DNA synthesis, folate metabolism and methylation reactions. Variants in MTHFR gene in the folate metabolic pathway show diverse geographical and ethnic distribution and in some cases have been linked to diseases. Two single nucleotide polymorphisms (SNPs) in the MTHFR gene, (C665T: rs 1801133 and A1298C: rs 1801131) are separately associated with an increased thermoliability and reduced biochemical activity of the enzyme.

Details

Verlag LAP LAMBERT Academic Publishing
Ersterscheinung 07. August 2018
Maße 22 cm x 15 cm x 0.5 cm
Gewicht 119 Gramm
Format Softcover
ISBN-13 9786139576210
Seiten 68