Morphometric Analysis Of AgNOR In Epithelial Dysplasia

Leukoplakia and other white lesions are always key of interest in oral pathology but an exciting new feature in this book is the morphometric analysis which increase the quality of prognosis. Nucleolar organizing region (NORs) are loops of DNA containing ribosomal RNA (r-RNA) genes. In humans, they are located on the short arm of the five acrocentric chromosomes which are chromosomes number 13, 14, 15, 21 & 22. Argyrophilic Nucleolar organizing region (AgNOR) are silver binding NORs. The NOR associated proteins probably act as regulators of r- DNA transcription or may have a role in maintaining the extended configuration of r-DNA. NOR staining identifies actively transcribing NORs & frequency of NORs per nucleus may reflect cell turnover & may hence, prove a useful replicatory marker. This book comprises complies of various studies and accurate data.