MicroRNAs and Telomerase Gene Expression in Alzheimer's Disease

Alzheimer's disease (AD) is an age-related neurodegenerative disorder marked by memory loss and cognitive impairment; it is the leading cause of dementia in the elderly. Due to the paucity of biological indicators for AD diagnosis in the region, predicting and diagnosing AD, particularly in its early stages, remains challenging. This study assessed the expression of specific microRNAs (miR-146a-5p and miR-125b-5p) and telomerase genes were taken (human telomerase reverse transcriptase (hTERT) and telomerase RNA component (TERC) as an early, non-invasive, new biomarker for the diagnosis and prediction of Alzheimer's disease.Our findings revealed that alterations in circulating levels of miR-146a-5p and miR-125b-5p might serve as early non-invasive diagnostic markers for the prediction of AD patients. Also, it shows down-regulation in hTERT and TERC gene expression levels in AD. We propose that telomerase gene expression in circulation can serve as a non-invasive, early, and novel diagnostic marker of AD.