Microparticulate Drug Delivery System

Rizatriptan benzoate is used for the treatment of migraine headaches. The oral bioavailability of rizatriptan benzoate is 45%. Conventional oral tablets of rizatriptan benzoate are effective and convenient for many patients with migraine. However, oral administrational of a conventional tablet may not be ideal for all patients. Swallowing a conventional tablet and water may exacerbate migraine-associated nausea and vomiting. Hence an alternative drug delivery system for rizatriptan benzoate is chosen to overcome drawbacks associated with conventional drug delivery. Thus in the present study, an attempt is being made by preparing chitosan-based microparticles for nasal drug delivery systems using spray drying.