Lewis acid Catalyzed Synthesis of Cinnoline Derivatives

An efficient synthesis of 4-benzyl cinnolines from aryl phenyl allylidene hydrazone is described. In this report stannous chloride used as a Lewis acid catalyst and both polar and nonpolar solvents are used for the synthesis. This method is expected to more advantageous than the other reported methods of synthesis of the cinnoline rings due to its low cost, and better yield and benign reaction conditions. To use stannous chloride as Lewis acid catalyst in the Michael addition reaction of indole with various nitro styrene derivatives. Reportedly, stannous chloride has an advantage over other common Lewis acid catalysts where catalytic amount of Bronsted acid is also necessary for efficient catalytic activity. Observing the effectivity of MW in organic synthesis, we have planned MW irradiation for some of our reactions