Iron Overload & Neurodegeneration

Life expectancy has increased in last decades and health care advancements have contributed to people living longer but this has also contributed to increase the number of people with chronic disabling diseases. Although systemic diseases have severely affected human health and well-being but a deteriorating brain is progressively becoming the arbitrator of death preceded by a gradual loss of the essence of being. Neurodegenerative disease is an umbrella term for a range of conditions which involves the degeneration of the neurons in the elderly human brain. Given that neurodegenerative disorders are common in elderly people and that disease-free brains, especially in the oldest old, are rare, it is possible that normal brain ageing forms a continuum with neurodegeneration and disease because of a person's genetics and environment, determine the type of neurodegenerative disease that will dominate their brain eventually