History, importance, and some basic concept of chirality

Chiral drugs are currently 50% used and near 90% of the last ones are marketed as racemates consisting of an equimolar mixture of two enantiomers. While they have the same scaffold, but they shows different biological activities such as pharmacology, toxicology, pharmacokinetics, metabolism etc. Therefore, it is significant to endorse the chiral separation and analysis of racemic drugs either in industry or in the clinic so as to eliminate the unwanted isomer from the groundwork and to find an optimal treatment and a right therapeutic control for the patient. In this article, we have briefly discussed the history of chirality, importance, and some basic concept of them. We have also included the importance of separation and various resolution methods.