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Heterogeneity in Asthma

Hardcover - 9781461486022
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Taschenbuch - 9781489978295
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Taschenbuch - 9781489978295
159,99 €


Asthma is a chronic relapsing airways disease that represents a major public health problem

worldwide. Intermittent exacerbations are provoked by airway mucosal exposure

to pro-inflammatory stimuli, with RNA viral infections or inhaled allergens representing

the two most common precipitants. In this setting, inducible signaling pathways

the airway mucosa play a central role in the initiation of airway inflammation

through production of antimicrobial peptides (defensins), cytokines, chemokines

and arachidonic acid metabolites that coordinate the complex processes of

vascular permeability, cellular recruitment, mucous hyper-secretion, bronchial

constriction and tissue remodeling. 

These signals also are responsible for leukocytic infiltration into the

submucosa, T helper-lymphocyte skewing, and allergic sensitization.

Currently, it

is well appreciated that asthma is a heterogeneous in terms of onset,

exacerbants, severity, and treatment response. 

Current asthma classification methods are largely descriptive and focus

on a single aspect or dimension of the disease. 

An active area of investigation on how to collect, use and visualize multidimensional

profiling in asthma.  This book will

overview multidimensional profiling strategies and visualization approaches for

phenotyping asthma.  As an outcome, this

work will facilitate the understanding of disease etiology, prognosis and/or

therapeutic intervention.  


Verlag Springer-Verlag GmbH
Ersterscheinung November 2013
Maße 244 mm x 161 mm x 22 mm
Gewicht 655 Gramm
Format Hardcover
ISBN-13 9781461486022
Auflage Nicht bekannt
Seiten 354