Hepatoprotective Potential of Annona Squmosa L.

Annona Sqamosa Linn. has been used for the treatment of cancer, diabetes, microbial infection, cardiac disease, jaundice, and other liver-related disorder. Hence the current work aims to explore the hepatoprotective of the Annona Sqamosa (AS) seeds. The study's main objective is to evaluate the hepatoprotective activity of the hydroalcoholic extract of seeds of Annona Squamosa Linn. using carbon tetrachloride-induced liver toxicity in rats. The activity was evaluated against carbon tetrachloride-induced hepatotoxicity by measuring the levels of serum enzymes such as SGOT, ALP, SGPT, and total bilirubin for liver function tests. Six groups of rats were used (n=6) and administered orally once daily with normal saline (normal control), carbon tetrachloride (toxic control), or ASE (100, 200, and 400 mg/kg) for 7 days, followed by the hepatotoxicity induction. Results: The extract showed significant hepatoprotective activity at 100 mg/kg, 200 mg/kg, and 400mg /kg b.w by decreasing the levels of SGOT, SGPT, ALP, and total bilirubin as compared to the toxic control group. The hydroalcoholic ASE extract has the potential of liver protection which could be attributed for investigation.