Hepatic Encephalopathy: Pathophysiology and Treatment

Hepatic Encephalopathy: Pathophysiology and Treatment

von Gilles Pomier Layrargues, Roger F. Butterworth
Taschenbuch - 9781461288510
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Beschreibung

Hepatic Encephalopathy (HE) is a neuropsychiatric disorder resul t­ ing from liver failure. HE may be associated with fulminant (acute) hepatic failure or chronic liver disease with portal-systemic shunting. The latter condition is characterized neuropathologically by astro­ cytic rather than neuronal changes (Alzheimer Type II astrocytosis). The former is frequently accompanied by cerebral edema. Several hypotheses have been proposed to explain the pathogene­ sis of HE. These include: 1. A toxic action of a substance (or substances) such as ammonia on brain function 2. A deficit of cerebral energy metabolism 3. Neurotransmitter changes, and, more recently 4. The role of "endogenous benzodiazepines. " This volume summarizes the results of a symposium held in Val David, Quebec from October 3D-November I, 1988, that was devoted to an evaluation of the evidence for and against the various hypothe­ ses of HE. Data from studies in patients, in experimental (animal) models of HE, and in cultured cell preparations were discussed. In addition, a review of available approaches to the treatment and man­ agement of HE was included. The therapeutic use of lactulose, anti­ biotics, dietary treatment, and branched-chain amino acid treatments were included, as well as the results of preliminary studies of the therapeutic use of the benzodiazepine antagonist, flumazenil. Roger F. Butterworth, PhD Gilles Pomier Layrargues, MD v Acknowledgments The symposium was made possible by the generous financial assistance of: Hoffman-La Roche Ltd.

Details

Verlag Humana Press
Ersterscheinung September 2011
Maße 235 mm x 155 mm x 34 mm
Gewicht 959 Gramm
Format Taschenbuch
ISBN-13 9781461288510
Auflage 1989
Seiten 644

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