Hemostatic Changes in Healthy Pregnant Women

Hemostasis in normal pregnancy involves a complex network of interactions with positive and negative feedback loops, integrating blood vessels; platelets, coagulation Factors, coagulation inhibitors and fibrinolysis; all these has evolved the likely to protect women from hemorrhage during miscarriage or childbirth. During delivery there is consumption of platelets and blood coagulation factors. Pregnancy is a risk factor for venous thrombosis and the incidence of venous thromboembolism during normal pregnancy is 6-fold higher than in the general female population of child bearing age. Venous thromboembolism is an important cause of maternal morbidity and mortality.