Gingival Crevicular Fluid

Periodontitis, the destructive category of periodontal disease, is a non-reversible inflammatory state of the supporting structures1, and is diagnosed clinically by the loss of attachment between the tooth and the supporting tissues (clinical attachment loss); by deepening of the pocket between the root of the tooth and the supporting tissues (pocket depth), and/or by radiographic evidence of bone loss2. Periodontal disease process is site specific and has multifactorial origin where periodontal pathogen, host response, genetic, systemic and behavioral risk factors interplay to develop the disease process. Hence, various measures have been taken to include microbial, immunologic, systemic, genetic and behavioral factors, in addition to traditional clinical and radiographic parameters, for assessing patient's periodontal status.