Genetic disorders in lung cancer patients (Smoking and non smoking)

Lung cancer is the leading cause of cancer death among both men and women. There will be an estimated 162,460 deaths from lung cancer (90,330 among men and 72,130 among women) in 2006 (WHO, February 2006), accounting for around 28% of all cancer deaths. More people die of lung cancer than of colon, breast, and prostate cancers combined. Lung cancer mainly occurs in the elderly. Nearly 70% of people diagnosed with lung cancer are older than 65; fewer than 3% of all cases are found in people under the age of 45. The chance that a man will develop lung cancer is 1 in 13 and for a woman, it is 1 in 17. CYP1A1gene is associated in Lung cancer risk in this CYP1A1 gene plays an important role in lung cancer patients. By using CYP1A1 gene identified the 3 cases are mutated and another 3 cases are wild types. CYP1A1 gene is a possible genetic risk factor for lung cancer susceptibility. Over expression of CYP1A1 gene has been reported in Lung cancer. By using the lung cancer patients blood samples can identified the genetic damage, and using of biochemical studies identified the Oxidative stress.