Gene Toxicity of Ionizing Radiation

Radiation of its different types is one of the major well known mutagenesis factors. Man exposes to different types of radiation which is used in diagnosis of diseases or treatment and the exposure through work or environmental is the other factor to mutagenesis. Low dose of ionizing radiation induces DNA damage on normal cells and abnormal cells. Healthy individuals show normal functions of genes manifested as normal gene expression of the very well-known DNA repair genes are the XRCC1, XRCC2 and FOXM1 regulator genes. In this work, other biomarkers for DNA damage were investigated, like level of 8-ohdG in urine samples, comet assay also performed in same samples and total of antioxidant capacity (TAC) was measured in serum.