Formulation and Evaluation of Clotrimazole Liposomes

The aim of the present work was the investigation of the effects of lipids and cholesterol for the development of liposomal formulations as potential carriers for anti-fungal agent Clotrimazole. Phospholipon 90H along with cholesterol were used for preparation of liposomes by film hydration method and characterized for drug content, entrapment efficiency, size, zeta potential, vesicle morphology, stability, FTIR, and in vitro drug release studies. The percentage drug content was found in the range of 99 to 101%, the Drug entrapment ranged between from 54.31±0.1% to 80.69±0.8%. The size was found in the range of 210 to 280µm. the drug release was found in the range of 84 to 99% up to 8 hrs. The prolonged drug release from liposomal dispersion could effectively exhibit the antifungal activity for prolonged periods for cutaneous delivery.