Experimental simulation of surgical sepsis

Until now, the solution to the problems associated with sepsis modeling has been based on the reproduction of bacteremia or sepsis in a wide range of understandings. The adoption of a new classification of sepsis and its forms by the Chicago consensus conference in 1991 allowed us to look at the problem in a very different, more promising way to solve problems. At the same time, the modeling of sepsis according to the known methods does not provide for the stages of the pathological process development with the development of the systemic inflammatory response syndrome. To fully assess the mechanisms of sepsis manifestation, it is necessary to develop a model corresponding to the initial stage of the systemic inflammatory reaction syndrome development against the background of the forming purulent-inflammatory focus. This problem is one of the topical issues not only in the field of modern experimental medicine, but also in the field of studying the pathogenesis of sepsis in general. The information presented in this monograph will be useful both for researchers engaged in the experimental modeling of pathological processes and for students of the Faculty of Medicine and Biology as additional educational literature.