Evaluation of the effect of concurrent use of cabergoline

The aim of this study was to investigate the effect of concurrent use of Melatonin and Cabergoline on expression of morphine induced conditioned place preference in male mice. In this experimental study, Male NMRI mice (20-30g) were used. The study took place on six consecutive days, consisting of three phases: preconditioning, conditioning, and post-conditioning. In first section of study, melatonin (2.5,10 and 30 mg/kg) and Cabergoline (2.5,5 and 10 mg/kg) alone were administered in conditioning and post-conditioning phases to see if they induced conditioned place preference (CPP) or aversion (CPA). In the second set, mice received melatonin and Cabergolin in post-conditioning phase after conditioning with morphine. Control groups received normal saline whereas these drugs. Intraperitoneal administration of different doses of morphine (5 and 10 mg/kg, p<0.001) induced CPP.