Enhanced Early Detection of Breast Carcinoma by Fork head Box Protein

Breast cancer was the most common type of cancer among females worldwide and was the fourth most common cause of cancer-related deaths. Therefore this study designed to evaluate the gene expressions and protein levels of Foxp3, TGF-¿ and VEGF genes in benign breast lesions and breast carcinoma as useful markers to enhance the early detection of breast cancer by different techniques and conducted on three groups; invasive breast carcinoma group, high risk patients with benign breast lesions and control group. In current study breast cancer patients recorded a highly significant increase in the mean value of serum VEGF, TGF-¿ and Foxp3 protein level and gene expressions when compared to the high risk and the control groups. Meanwhile, the high risk had intermediate mean value of VEGF, TGF-¿ and Foxp3 protein levels and gene expressions between breast cancer and healthy control. These results confirmed with three different techniques (ELISA, qRT-PCR and Flow cytometer). Therefore the levels of VEGF, TGF-¿ and Foxp3 could be used as, quantitative, accurate, and a sensitive biomarkers and robust assay for the early detection of breast cancer especially in high risk patients .